Assistant Professor, Computational and Systems Biology, and Department of Infectious Diseases and Microbiology -(Secondary Appointment)
Member, Center for Vaccine Research

Email: Elg21@pitt.edu
Phone: 412-383-5850
Fax: 412-383-5851

Address:
BST3, Room 9043b
3501 5th Avenue
Pittsburgh, PA 15261


Education

Ph.D., Molecular Parasitology, McGill University, Montreal, QC - 1998
M.Sc., Environmental Sciences, UQAM, Montreal, QC - 1993
B.Sc., Biology, McGill University, Montreal, QC - 1989


Research Interests

RNA Virus Evolution, Molecular Epidemiology
Parasite Genomics
Metagenomics and Virus Discovery

The focus of the Ghedin laboratory is on defining genomic characteristics of human parasites and other pathogens. Our research is multidisciplinary and draws upon the tools of genomics, molecular virology, and computational biology. Projects include the study of RNA virus evolution and emergence, the discovery of new retroelements in parasite genomes, and the characterization of endosymbiotic host-parasite interactions.


Selected Publications

Ghedin, E., Sengamalay, N.A., Shumway, M., Zaborsky, J., Feldblyum, T., Subbu, V., Spiro, D.J., Sitz, J., Koo, H., Bolotov, P., Dernovoy, D., Tatusova, T., Bao, Y., St. George, K., Taylor, J., Lipman, D.J., Fraser, C.M., Taubenberger, J.K., Salzberg, S.L. (2005) Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature Oct 20;437(7062):1162-6.

Holmes, E.C., Ghedin, E., Miller, N., Taylor, J., Bao, Y., George, K.S., Grenfell, B.T., Salzberg, S.L., Fraser, C.M., Lipman, D.J., Taubenberger, J.K. (2005) Whole-Genome Analysis of Human Influenza A Virus Reveals Multiple Persistent Lineages and Reassortment among Recent H3N2 Viruses. PLoS Biol. Jul 26;3(9):e300.

Berriman, M., Ghedin, E., .[+77 authors]…El-Sayed, N.M.A. (2005) The genome sequence of the African trypanosome, Trypanosoma brucei. Science Jul 15;309(5733):416-422.

Bringaud, F., Bartholomeu, D., Blandin, G., Delcher, A., Baltz, T., El-Sayed, N.M.A.and Ghedin, E. (2006). The Trypanosoma cruzi L1Tc and NARTc Non-LTR Retrotransposons Show Relative Site-Specificity for Insertion. Mol Biol Evol Feb;23(2):411-420.

Bringaud, F., Müller, M., Coutinho Cerqueira, G., El-Sayed, N.M.A., Papadopoulou, B., and Ghedin, E. (2007) A Large Family of Extinct Short Retroposons is Involved in the Regulation of Gene Expression in Leishmania. PLoS Pathogens, Sep 7;3(9):e136.

Salzberg, S.L., Kingsford, C., Cattoli,G., Spiro, D.J., Janies, D.J., Mehrez Aly, M., Brown, I.H., Couacy-Hymann, E., De Mia, G.M., Dung, D.H., Guercio, A., Joannis, T., Ali, A.S.M., Osmani, A., Padalino, I., Saad, M.D., Savi?, V., Sengamalay, N.A., Yingst, S., Zaborsky, J., Zorman-Rojs, O., Ghedin, E., Capua, I. (2007) Genome Analysis Linking Recent European and African Influenza H5N1 Viruses. Emerging Infectious Diseases 13: 713-718.

Ghedin, E., Wang, S., Spiro, D.J., …[+63 co-authors]…Blaxter, M, Scott, A. (2007) Draft Genome Sequence of the Filarial Nematode Parasite Brugia malayi. Science 317:1756-1760.

Ghedin, E., Daehnel, K., Foster, H., Slatko, B., Lustigman, S. (2008) The symbiotic relationship between filarial parasitic nematodes and their Wolbachia endosymbionts - a resource for a new generation of control measures. Symbiosis 46:77-85.

Ghedin, E., Fitch, A., Boyne, A., Griesemer, S., DePasse, J., Bera, J., Zhang, X., Halpin, R.A., Smit, M., Jennings, L., St George, K., Holmes, E.C., Spiro, D.J. (2009) Mixed infection and the genesis of influenza virus diversity. J Virol. Sep;83(17):8832-41. Epub 2009 Jun 24.

Ghedin, E., Hailemariam, T., DePasse, J.V., Zhang, X., Oksov, Y., Unnasch, T.R., Lustigman, S. (2009) Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment. PLoS Negl Trop Dis. Oct 6;3(10):e525.

Ghedin, E., Wentworth, D.E., Halpin, R.A., Lin, X., Bera, J., DePasse, J., Fitch, A., Griesemer, S., Hine, E., Katzel, D.A., Overton, L., Proudfoot, K., Sitz, J., Szczypinski, B., StGeorge, K., Spiro, D.J., Holmes, E.C. (2010) Unseasonal transmission of H3N2 influenza A virus during the swine-origin H1N1 pandemic. J Virol. Jun;84(11):5715-8. Epub 2010 Mar 17.