Professor, Department of Infectious Diseases and Microbiology and
Department of Epidemiology (Secondary Appointment)

Head, of the AIDS Malignancy Program

Email: kingsley@pitt.edu
Phone: 412-624-5069
Fax: 412-624-4953

Address:
418 Crabtree Hall
130 DeSoto St.
Pittsburgh, PA 15261

Education

BS; Pennsylvania State University; 1972
MPH; University of Pittsburgh; 1981
DrPH; University of Pittsburgh; 1983


Research Interests

Applications of infectious disease epidemiology, with particular emphasis on the natural history of HIV infection, STDs, HBV, HHV-8 and HIV/HAART-associated metabolic complications.


Research Summary

Dr. Kingsley has been directly involved in unraveling the complex natural history of Acquired Immune Deficiency Syndrome (AIDS) since 1983. As the epidemiologist and Co-Principal Investigator for the Pitt Men's Study, which is a part of the Multicenter AIDS Cohort Study (MACS), he has investigated several key areas of HIV infection including risk factors for sexual transmission, determinants of disease progression, impact of behavioral changes on the AIDS epidemic, predictors of immunologic decline, and the natural history of the AIDS-associated malignancies non-Hodgkins lymphoma and Kaposi's sarcoma. Recently, the metabolic complications of HIV and antiretroviral therapies (dyslipidemia, insulin resistance/diabetes mellitus) have raised awareness of the potential for increased cardiovascular disease risk. These metabolic problems have become a major component of the MACS Metabolic Working Group which Dr Kingsley chairs. Additional active research interests include hepatitis B virus, otitis media and bacterial pneumonia.


Recent Publications

Riddler, S.A., Smit, E., Cole, S.R., Li, R., Chmiel, J.S., Dobs, A., Palella, F., Visscher, B., Evans, R., and Kingsley, L.A. (2003). Impact of HIV infection and HAART on serum lipids in men. JAMA 289:2978-2982.

Morris, A., Kingsley, L.A., Groner, G., Lebedeva, I.P., Beard, C.B., and Norris, K.A. (2004) Prevalence and clinical predictors of Pneumocystis colonization among HIV-infected men. AIDS. 18:793-798.

Brown, T.T., Li, X., Cole, S.R., Kingsley, L.A., Palella, F.J., Riddler, S.R., Chmiel, J.S., Visscher, B.R., Margolick, J., and Dobs, A.S. (2005) Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the Multicenter AIDS Cohort Study. Archives Intern Med 65:1179-1184.

Palella, F.J., Chmiel, J.S., Riddler, S.A., Calhoun, B.C., Dobs, A., Visscher, B.R., and Kingsley, L.A. (2005) New pattern of lipoaccumulation in HIV-infected persons with body habitus changes. JAMA 296(7);766-768, 2006

Brown, T.T., Li, X., Cole, S.R., Kingsley, L.A., Palella, F.J., Riddler, S.A., Chmiel, J.S., Visscher, B.R., Margolick, J.B., and Dobs, A.S. (2005) Cumulative exposure to nuculeoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study. AIDS 19:1375-1383.

Lau, B., Sharrett, A.R., Kingsley, L.A., Post, W., Palella, F.J., Visscher, B., and Gange, S.J. (2006) C-reactive protein is a marker for human immunodeficiency virus disease progression. Arch. Intern. Med. 166:64-70.

Steel, J.L., Landsittel, D., Calhoun, B., Wieand, S., and Kingsley, L.A. (2006) Effects of lipodystrophy on quality of life and depression in HIV-infected men on HAART. AIDS Patient Care STDs. 20:565-575.

Laney, A.S., Peters, J.S., Manzi, S.M., Kingsley, L.A., Chang, Y., and Moore, P.S. (2006) Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection. J. Clin. Microbiol. 44:3734-3741, 2006.

Riddler, S.A., Li, X., Chu, H., Kingsley, L.A., Dobs, A., Evans, R., Palella, F., Visscher, B., Chmiel, J.S., and Sharrett, A. (2007) Longitudinal changes in serum lipids among HIV-infected men on highly active antiviral therapy. HIV Med. 8:280-287

Kaplan, R.C., Kingsley, L.A., Sharrett, A.R., Li, X., Lazar, J., Tien, P.C., Mack, W.J., Cohen, M.H., Jacobson, L., and Gange, S.J. Ten-year predicted coronary heart disease risk in HIV-infected men and women. Clin. Infect. Dis. 45:1074-1081, 2007

T. Brown, H. Chu, Z Wang, F. Palella, L. Kingsley, M. Witt, A. Dobs Longitudinal Increases in Waist Circumference are Associated with HIV-serostatus, Independent of Antiretroviral Therapy in the Multicenter AIDS Cohort Study: -in press, AIDS

Kingsley LA, Cuervo J, Munoz A, Palella FJ, Post W, Witt M , Budoff M and Kuller LH. Subclinical Coronary Atherosclerosis, HIV-infection and Antiretroviral Therapy: Results From the Multicenter AIDS Cohort Study. AIDS 22(13):1589-1599, 2008 August 20

Kaplan RC, Kingsley LA, Gange SJ, Benning L, Jacobson LP, Lazar J, Anastos K, Tien PC, Sharrett AR, Hodis HN. Subclinical carotid atherosclerosis in HIV-infected and HIV-uninfected women and men: AIDS 22(13):1615-1624, 2008 August 20

Riddler SA Li X , Otvos J, Palella F, Kingsley LA, Visscher B, Jacobson L, Sharrett AR: Antiretroviral Therapy is Associated with an Atherogenic Lipoprotein Phenotype among HIV-1 Infected Men in the Multicenter AIDS Cohort Study. Journal of Acquired Immune Deficiency Syndromes: JAIDS. 48(3):281-8, 2008 Jul 1.

Longenberger A, Lim JY, Orchard T, Brooks MM, Brach J, Mertz K and Kingsley LA: Self-reported Low Physical Function is Associated with Diabetes Mellitus and Insulin resistance in HIV-positive and HIV-negative Men. Future HIV Therapy 2009;2(6);539-549

Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, Poole JC, Lautenberger J, Sezgin E, Nelson G, Kingsley LA, Jacobson L, Phair J, Goedert J, Vlahov D, Donfield S, Buchbinder SP, Wallace DC, and O’Brien SJ: Mitochondrial DNA Haplogroups influence AIDS Progression. AIDS. 22(18):2429-39, 2008 Nov 30

Hendrickson SL, Kingsley LA, Ruiz-Pesini E, Poole JC, Jacobson LP, Palella FJ, Bream JH, Wallace DC and. O’Brien SJ: AIDS Mitochondrial DNA Haplogroups influence lipoatrophy after Highly Active Anti-retroviral Therapy. J Acquir Immune Defic Syndr 2009;51:111–116)