Faculty

Elodie Ghedin, PhD Assistant Professor, of Medicine and Computational Biology Affiliate, Center for Vaccine Research, and Department of Infectious Diseases and Microbiology -(Secondary Appointment) E-mail: elg21@pitt.edu Phone: 412-383-5850 Fax: 412-383-5851 Address: Scaife Hall, Room 830 3550 Terrace Street Pittsburgh, PA 15261

Education

Ph.D., Molecular Parasitology, McGill University, Montreal, QC - 1998
M.Sc., Environmental Sciences, UQAM, Montreal, QC - 1993
B.Sc., Biology, McGill University, Montreal, QC - 1989

Research Interests

RNA Virus Evolution, Molecular Epidemiology
Parasite Genomics
Metagenomics and Virus Discovery

The focus of the Ghedin laboratory is on defining genomic characteristics of human parasites and other pathogens. Our research is multidisciplinary and draws upon the tools of genomics, molecular virology, and computational biology. Projects include the study of RNA virus evolution and emergence, the discovery of new retroelements in parasite genomes, and the characterization of endosymbiotic host-parasite interactions.

Recent Publications

• Ghedin, E., Sengamalay, N.A., Shumway, M., Zaborsky, J., Feldblyum, T., Subbu, V., Spiro, D.J., Sitz, J., Koo, H., Bolotov, P., Dernovoy, D., Tatusova, T., Bao, Y., St. George, K., Taylor, J., Lipman, D.J., Fraser, C.M., Taubenberger, J.K., Salzberg, S.L. (2005) Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature Oct 20;437(7062):1162-6.
  
• Holmes, E.C., Ghedin, E., Miller, N., Taylor, J., Bao, Y., George, K.S., Grenfell, B.T., Salzberg, S.L., Fraser, C.M., Lipman, D.J., Taubenberger, J.K. (2005) Whole-Genome Analysis of Human Influenza A Virus Reveals Multiple Persistent Lineages and Reassortment among Recent H3N2 Viruses. PLoS Biol. Jul 26;3(9):e300.
  
• Berriman, M., Ghedin, E., .[+77 authors]…El-Sayed, N.M.A. (2005) The genome sequence of the African trypanosome, Trypanosoma brucei. Science Jul 15;309(5733):416-422.
  
• Ghedin, E. and Claverie, J.-M. (2005) Mimivirus Relatives in the Sargasso Sea. Virology J Aug 16;2(1):62.
  
• Huete-Perez, J., Flores-Obando, R.E., Ghedin, E., Caffrey, M. (2005) Genomic and Proteomic Approaches for Chagas’ disease: critical analysis of diagnostic methods. Expert Review of Molecular Diagnostics Jul;5(4):521-530.
  
• El-Sayed, N.M.A., Myler, P.J., Blandin, G., Berriman, M., Crabtree, J., Aggarwal, G., Caler, E., Renauld, H., Worthey, E.A., Hertz-Fowler, C., Ghedin, E., Peacock, C., Haas, B., Angiuoli, S., Anupama, A., Bartholomeu, D., Cadag, E., Carlton, J.M., Creasy, T., Djikeng, A., Hauser, C., Ivens, A.C., Kummerfeld, S., Leal, J., Nilsson, D., Peterson, J., Shallom, J., Silva, J.C., Sundaram, J., Tran, A.-N., Westenberger, S., White, O., Wortman, J., Melville, S.E., Donelson, J.E., Andersson, B., Stuart, K.D., and Hall, N. (2005) Comparative genomics of the trypanosomatids. Science Jul 15;309(5733):404-409.
  
• Bringaud, F., Bartholomeu, D., Blandin, G., Delcher, A., Baltz, T., El-Sayed, N.M.A.and Ghedin, E. (2006). The Trypanosoma cruzi L1Tc and NARTc Non-LTR Retrotransposons Show Relative Site-Specificity for Insertion. Mol Biol Evol Feb;23(2):411-420.
  
• Bringaud, F., Ghedin, E., Blandin, G., Bartholomeu, D., Levin, M.J., Baltz, T. and El-Sayed, N.M.A. (2006) Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements. Mol Biochem Parasitol Epub 2005 Oct 10.
  
• Salzberg, S.L., Kingsford, C., Cattoli,G., Spiro, D.J., Janies, D.J., Mehrez Aly, M., Brown, I.H., Couacy-Hymann, E., De Mia, G.M., Dung, D.H., Guercio, A., Joannis, T., Ali, A.S.M., Osmani, A., Padalino, I., Saad, M.D., Savić, V., Sengamalay, N.A., Yingst, S., Zaborsky, J., Zorman-Rojs, O., Ghedin, E., Capua, I. (2007) Genome Analysis Linking Recent European and African Influenza H5N1 Viruses. Emerging Infectious Diseases 13: 713-718.
  
• Bringaud, F., Müller, M., Coutinho Cerqueira, G., El-Sayed, N.M.A., Papadopoulou, B., and Ghedin, E. (2007) A Large Family of Extinct Short Retroposons is Involved in the Regulation of Gene Expression in Leishmania. PLoS Pathogens, Sep 7;3(9):e136.
  
• Salzberg, S.L., Kingsford, C., Cattoli,G., Spiro, D.J., Janies, D.J., Mehrez Aly, M., Brown, I.H., Couacy-Hymann, E., De Mia, G.M., Dung, D.H., Guercio, A., Joannis, T., Ali, A.S.M., Osmani, A., Padalino, I., Saad, M.D., Savić, V., Sengamalay, N.A., Yingst, S., Zaborsky, J., Zorman-Rojs, O., Ghedin, E., Capua, I. (2007) Genome Analysis Linking Recent European and African Influenza H5N1 Viruses. Emerging Infectious Diseases 13: 713-718.
  
• Dunning Hotopp, J.C., Clark, M.E., Oliveira, D.C.S.G. Foster, J.M., Fischer, P., Muñoz Torres, M.C., Giebel, J.D., Wang, S., Ingram, J., Nene, R.H., Shepard, J., Ishmael, N., Kumar, N., Tomkins, J., Richards, S., Spiro, D.J., Ghedin, E., Slatko, B.E., Tettelin, H., Werren, J.H. (2007) Widespread Lateral Gene Transfer from Intracellular Bacteria to Multicellular Eukaryotes. Science, 317:1753-1756.
• Ghedin, E., Wang, S., Spiro, D.J., …[+63 co-authors]…Blaxter, M, Scott, A. (2007) Draft Genome Sequence of the Filarial Nematode Parasite Brugia malayi. Science 317:1756-1760.
• Nelson, M.I., Viboud, C., Simonsen, L., Bennett, R.T., Griesemer, S.B., St. George, K., Taylor, J., Spiro, D.J., Sengamalay, N.A., Ghedin, E., Taubenberger, J.K., Holmes, E.C. (2008) Multiple Reassortment Events in the Evolutionary History of H1N1 Influenza A Virus Since 1918. PLoS Pathogens. Feb 29;4(2):e1000012.
• Ghedin, E., Daehnel, K., Foster, H., Slatko, B., Lustigman, S. (2008) The symbiotic relationship between filarial parasitic nematodes and their Wolbachia endosymbionts – a resource for a new generation of control measures. Symbiosis 46:77-85.