Lawrence Kingsley, DrPH Associate Professor, Department of Infectious Diseases and Microbiology and Department of Epidemiology (Secondary Appointment) and Director of IDM MPH Bioscience of Infectious Diseases Program Head, of the AIDS Malignancy Program E-mail: kingsley@pitt.edu Phone: 412-624-5069 Fax: 412-624-4953 Address: 418 Crabtree Hall 130 DeSoto St. Pittsburgh, PA 15261

Education

BS; Pennsylvania State University; 1972
MPH; University of Pittsburgh; 1981
DrPH; University of Pittsburgh; 1983

Research Interests

Applications of infectious disease epidemiology, with particular emphasis on HIV infection, STDs, HBV, HHV-8 and HIV-associated malignancies.

Research Summary

Dr. Kingsley has been directly involved in unraveling the complex natural history of Acquired Immune Deficiency Syndrome (AIDS) since 1983. As the epidemiologist and Co-Principal Investigator for the Pitt Men's Study, which is a part of the Multicenter AIDS Cohort Study (MACS), he has investigated several key areas of HIV infection including risk factors for sexual transmission, determinants of disease progression, impact of behavioral changes on the AIDS epidemic, predictors of immunologic decline, and the natural history of AIDS-associated malignancies non-Hodgkins lymphoma and Kaposi's sarcoma. Recently, the metabolic complications of HIV and antiretroviral therapies (dyslipidemia, insulin resistance/diabetes mellitus) have raised awareness of the potential for increased cardiovascular disease risk.  The metabolic problems have become a major component of the MACS Metabolic Working Group which Dr Kingsley chairs.  Additional active research interests include hepatitis B virus, otitis media and bacterial pneumonia.

Recent Publications

• Wang, Q.J., Jenkins, F.J., Jacobson, L.P., Kingsley, L.A., Day, R.D., Zhang, Z-W., Meng, Y-X., Pellet, P.E., Kousoulas, K.G., Baghian, A., and Rinaldo, Jr. C.R. (2001).  Primary human herpesvirus 8 infection generates a broadly specific CD8+ T-cell response to viral lytic cycle proteins. Blood 97:2366-2373.
• Rose, C., Green, M., Webber, S., Kingsley, L., Day, R., Watkins, S., Reyes, J., and Rowe, D.  (2002). Detection of Epstein-Barr virus genomes in peripheral blood B cells from solid-organ transplant recipients by fluorescence in situ hybridization. J. Clin. Microbiol. 40:2533-2544.
• Wadowsky, R.M., Castilla, E.A., Laus, S., Kozy, A., Atchison, R.W., Kingsley, L.A., Ward, J.I., and Greenberg, D.P.  (2002). Evaluation of Chlamydia pneumoniae and Mycoplasma pneumoniae as etiologic agents of persistent cough in adolescents and adults. J. Clin. Microbiol. 40:637-640.
• Cole, S.R., Hernan, M.A., Robins, J.M., Anastos, K., Chmiel, J., Detels, R., Ervin, C., Feldman, J., Greenblatt, R., Kingsley, L., Lai, S., Young, M., Cohen, M., and Munoz, A. (2003).  Effect of highly active antiretroviral therapy on time to acquired immunodeficiency syndrome or death using marginal structural models. Am. J. Epidemiol.  158:687-694.
• Gupta, P., Kingsley, L., Sheppard, H.W., Harrison, L.H., Chatterjee, R., Ghosh, A., Roy, P., and Neogi, D.K.  (2003). High incidence and prevalence of HIV-1 infection in high risk population in Calcutta, India. Int. J. STD AIDS  14:463-468.
• Riddler, S.A., Smit, E., Cole, S.R., Li, R., Chmiel, J.S., Dobs, A., Palella, F., Visscher, B., Evans, R., and Kingsley, L.A. (2003). Impact of HIV infection and HAART on serum lipids in men. JAMA  289:2978-2982.
• Morris, A., Kingsley, L.A., Groner, G., Lebedeva, I.P., Beard, C.B., and Norris, K.A. (2004) Prevalence and clinical predictors of Pneumocystis colonization among HIV-infected men. AIDS. 18:793-798.
• Brown, T.T., Li, X., Cole, S.R., Kingsley, L.A., Palella, F.J., Riddler, S.R., Chmiel, J.S., Visscher, B.R., Margolick, J., and Dobs, A.S. (2005) Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the Multicenter AIDS Cohort Study. Archives Intern Med 65:1179-1184.
• Palella, F.J., Chmiel, J.S., Riddler, S.A., Calhoun, B.C., Dobs, A., Visscher, B.R., and Kingsley, L.A. (2005) New pattern of lipoaccumulation in HIV-infected persons with body habitus changes. JAMA  296(7);766-768, 2006
• Brown, T.T., Li, X., Cole, S.R., Kingsley, L.A., Palella, F.J., Riddler, S.A., Chmiel, J.S., Visscher, B.R., Margolick, J.B., and Dobs, A.S.  (2005)  Cumulative exposure to nuculeoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study.  AIDS  19:1375-1383. 
• Lau, B., Sharrett, A.R., Kingsley, L.A., Post, W., Palella, F.J., Visscher, B., and Gange, S.J.  (2006)  C-reactive protein is a marker for human immunodeficiency virus disease progression.  Arch. Intern. Med. 166:64-70.
• Steel, J.L., Landsittel, D., Calhoun, B., Wieand, S., and Kingsley, L.A.  (2006)  Effects of lipodystrophy on quality of life and depression in HIV-infected men on HAART.  AIDS Patient Care STDs.  20:565-575.
• Laney, A.S., Peters, J.S., Manzi, S.M., Kingsley, L.A., Chang, Y., and Moore, P.S.  (2006)  Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection.  J. Clin. Microbiol.  44:3734-3741, 2006.
• Riddler, S.A., Li, X., Chu, H., Kingsley, L.A., Dobs, A., Evans, R., Palella, F., Visscher, B., Chmiel, J.S., and Sharrett, A.  (2007)  Longitudinal changes in serum lipids among HIV-infected men on highly active antiviral therapy.  HIV Med.  8:280-287.
• Kaplan, R.C., Kingsley, L.A., Sharrett, A.R., Li, X., Lazar, J., Tien, P.C., Mack, W.J., Cohen, M.H., Jacobson, L., and Gange, S.J.  Ten-year predicted coronary heart disease risk in HIV-infected men and women.  Clin. Infect. Dis.  45:1074-1081, 2007.
• T. Brown, H. Chu, Z Wang, F. Palella, L. Kingsley, M. Witt, A. Dobs Longitudinal Increases in Waist Circumference are Associated with HIV-serostatus, Independent of Antiretroviral Therapy in the Multicenter AIDS Cohort Study: -in press, AIDS
• Kaplan RC, Kingsley LA, Gange SJ, Benning L, Jacobson LP, Lazar J, Anastos K, Tien PC, Sharrett AR, Hodis HN. Subclinical carotid atherosclerosis in HIV-infected and HIV-uninfected women and men: AIDS 22(13):1615-1624, 2008 August 20
• Kaplan RC, Kingsley LA, Gange SJ, Benning L, Jacobson LP, Lazar J, Anastos K, Tien PC, Sharrett AR, Hodis HN. Subclinical carotid atherosclerosis in HIV-infected and HIV-uninfected women and men: AIDS 22(13):1615-1624, 2008 August 20
• Riddler SA Li X , Otvos J, Palella F, Kingsley LA, Visscher B, Jacobson L, Sharrett AR: Antiretroviral Therapy is Associated with an Atherogenic Lipoprotein Phenotype among HIV-1 Infected Men in the Multicenter AIDS Cohort Study. Journal of Acquired Immune Deficiency Syndromes: JAIDS. 48(3):281-8, 2008 Jul 1.
• Longenberger A, Lim JY, Orchard T, Brooks MM, Brach J, Mertz K and Kingsley LA: Self-reported Low Physical Function is Associated with Diabetes Mellitus and Insulin resistance in HIV-positive and HIV-negative Men. Future HIV Therapy 2009;2(6);539-549
• Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, Poole JC, Lautenberger J, Sezgin E, Nelson G, Kingsley LA, Jacobson L, Phair J, Goedert J, Vlahov D, Donfield S, Buchbinder SP, Wallace DC, and O’Brien SJ: Mitochondrial DNA Haplogroups influence AIDS Progression. AIDS. 22(18):2429-39, 2008 Nov 30
• Hendrickson SL, Kingsley LA, Ruiz-Pesini E, Poole JC, Jacobson LP, Palella FJ, Bream JH, Wallace DC and. O’Brien SJ: AIDS Mitochondrial DNA Haplogroups influence lipoatrophy after Highly Active Anti-retroviral Therapy. J Acquir Immune Defic Syndr 2009;51:111–116)