Patrick S. Moore, MD, MPH Professor, Department of Microbiology and Molecular Genetics - School of Medicine and Department of Infectious Diseases and Microbiology - Graduate School of Public Health (Secondary Appointment) E-mail: psm9@pitt.edu Phone: 412-623-7721 Fax: 412-623-7715 Web site: www.kshv.pitt.edu/ Address: Hillman Cancer Center Research Pavillion 5117 Centre Avenue, Suite 1.4 Pittsburgh, PA 15213-1863

Education

MS; Stanford University; 1980
MD; University of Utah School of Medicine; 1985
MPH; University of California, Berkeley; 1990

Research Interests

Investigation of basic interactions between KSHV and host cell signaling pathways that contribute to cancer cell development; discovery of new pathogens in chronic diseases (cancers, autoimmune disorders) using molecular methods

Research Summary

Studies under the support of the Multicenter AIDS Cohort Study (MACS) are being conducted to elucidate the mechanism of HIV-induced pathogenesis at the cellular and molecular level.

Recent Publications

• Iscovich, J., Fischbein, A., Fisher-Fischbein, J., Freedman, L., Eng, S., Boffetta, P., Vudovich, A., Glasman, C., Goldschmidt, R., Livingston, M., Heger-Maslansky, B., Brennan, P., and Moore, P.S. (2000). Seroprevalence of Kaposi's Sarcoma-associated herpesvirus in healthy adults in Israel. Anticancer Res. 20:2119-2122.
• Olsen, S.J., Sarid, R., Chang, Y., and Moore, P.S. (2000). Evaluation of the Latency-Associated Nuclear Antigen (ORF73) of Kaposi's Sarcoma-associated herpesvirus by peptide mapping and bacterially expressed recombinant western blot assay. J. Infect. Dis. 182:306-310.
• Parravicini, C., Chandran, B., Corbellino, M., Berti, M., Moore, P.S., and Chang, Y. (2000). Differential viral protein expression in KSHV-associated diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am. J. Path. 156:743-749.
• Stine, J.T., Wood, C., Raport, C., Epp, A., Schweickart, V., Endo, Y., Sasaki, T., Simmons, G., Boshoff, C., Clapham, P., Chang, Y., Moore, P.S., Gray, P.W., and Chantry, D. (2000). KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood 95:1151-1157.
• Rivas, C., Thlick, A.E., Parravicini, C., Moore, P.S., and Chang, Y. (2001). KSHV LANA2 is a B-cell specific latent viral protein that inhibits p53. J. Virol. 75:429-438.
• Chatterjee, M., Osborne, J., Bestetti, G., Chang, Y., and  Moore, P.S. (2002). Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science 298:1432-1435.
• Moore, P.S. and Chang Y. (2003). Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: Two sides of the same coin? Annu. Rev. Microbiol. 57:609-639.

• Kouri, V., Eng, S.M., Rodriguez, M.E., Resik, S., Orraca, O., Moore, P.S., and Chang, Y.  (2004). Seroprevalence of Kaposi's sarcoma-associated herpesvirus in various populations in Cuba. Rev. Panam Salud Publica  15:320-325.

• Laney, A.S., De Marco, T., Peters, J.S., Malloy, M., Teehankee, C., Moore, P.S., and Chang, Y. (2005).  Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension.  Chest 127:762-767.