Faculty

A. William Pasculle, ScD Associate Professor, Department of Pathology - School of Medicine and Department of Infectious Diseases and Microbiology - Graduate School of Public Health (Secondary Appointment) Director, Clinical Microbiology E-mail: pasculleaw@upmc.edu Phone: 412-647-6610 Address: A807 Scaife Hall University of Pittsburgh Medical Center Department of Pathology Division of Clinical Microbiology Pittsburgh PA 15213

Education

BS; Waynesburg University; 1969
MSHyg; University of Pittsburgh; 1971
ScDHyg; University of Pittsburgh; 1976

Research Interests

Host defenses and virulence factors of Legionella infections; clinical microbiology

Research Summary

Dr. Pasculle was responsible for the discovery of Legionella micdadei in 1979. He also serves as the associate director of the clinical microbiology laboratory at Presbyterian-University Hospital. His research interests have included pathologic and microbiological studies Legionella as well as several areas of Clinical Microbiology. Most recently he has been studying the use of DNA probes for the detection of Legionella and other bacterial in clinical specimens.

Recent Publications

• Panackal, A.A., Mikanatha, N.M., Tsui, F.C., McMahon, J., Wagner, M.M., Dixon, B.W., Zubieta, J., Phelan, M., Mirza, S., Morgan,  J., Jernigan, D., Pasculle, A.W., Rankin, J.T. Jr., Hajjeh, R.A., and Harrison, L.H. (2002).  Automatic electronic laboratory-based reporting of notifiable infectious diseases at a large health system. Emerg. Infect. Dis. 8:685-691.

• Paterson, D.L., Pasculle, A.W., and McCurry, K. (2003) Linezolid: the first oxazolidinone antimicrobial. Ann Intern Med. 139:863-864. 

• Szabo, D., Bonomo, R.A., Silveira, F., Pasculle, A.W., Baxter, C., Linden, P.K., Hujer, A.M., Hujer, K.M., Deeley, K., and Paterson, D.L.  (2005)  SHV-type extended-spectrum beta-lactamase production is associated with Reduced cefepime susceptibility in enterobacter cloacae.  J. Clin. Microbiol.  43:5058-5064.

• Muto, C.A., Pokrywka, M., Shutt, K., Mendelsohn, A.B., Nouri, K., Posey, K., Roberts, T., Croyle, K., Krystofiak, S., Patel-Brown, S., Pasculle, A.W., Paterson, D.L., Saul, M., and Harrison, L.H.   (2005) A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use. Infect. Control Hosp. Epidemiol. 26:273-280.