Faculty

Sharon Riddler, MD Assistant Professor, Department of Medicine, Division of Infectious Diseases - School of Medicine, and Department of Infectious Diseases and Microbiology - Graduate School of Public Health Medical Director, Pitt Men's Study Co-investigator, Pitt Treatment Evalution Unit, UPMC E-mail: riddler@msx.dept-med.pitt.edu Phone: 412-647-6710 Fax: 412-647-5519 Address: Division of Infectious Diseases 3601 Fifth Avenue 613 Falk Medical Building Pittsburgh, PA 15213

Education

BS; Marquette University; 1982
MD; Medical College of Wisconsin; 1986

Research Interests

Treatment of HIV/AIDS: HIV clinical Trials; Immune based therapies for HIV infection; complications of antiretroviral therapy

Research Summary

Sharon A. Riddler, M.D., is an Assistant Professor of Medicine in the Division of Infectious Diseases and a Research Assistant Professor in the Department of Infectious Diseases and Microbiology in the Graduate School of Public Health at the University of Pittsburgh. She has a strong interest in HIV clinical care and clinical research. She is an investigator with the Pitt Treatment Evaluation Unit and is the Medical Director of the Pitt Men's Study, a Multicenter AIDS Cohort Study site. She provides primary care to HIV-infected individuals and is a co-investigator of the Pitt HIV Early Intervention Project funded by a HRSA Ryan White Title III grant.

Recent Publications

• Rinaldo, C.R., Huang, X-L., Fan, Z., Margolick, J.B., Al-Shboul, Q., Zheng, L., McMahon, D.K., Riddler, S.A., and Mellors, J.W. (2000). Enhancement of anti-HIV-1 cytotoxic T lymphocyte reactivity after combination antiretroviral therapy. J. Virol., in press.
• Rinaldo, C.R., Huang, X-L., Fan, Z., Margolick, J.B., Borowski, L., Hoji, A., Kalinyak, C., McMahon, D.K., Riddler, S.A., Hildebrand, W.H., Day, R.B., and Mellors, J.W. (2000). Anti-human immunodeficiency virus type 1 (HIV-1) CD8+ T-lymphocyte reactivity during combination antiretroviral therapy in HIV-1 infected patients with advanced immunodeficiency. J. Virol. 5:4127-4138.
• Hennessey, K.A., Giorgi, J.V., Kaplan, A.H., Visscher, B.R., Gange, S., Margolick, J.B., Riddler, S., Phair, J.. and Detels, R. (2000). AIDS onset at high CD4+ cell levels is associated with high HIV load. AIDS Res. Hum. Retrov. 16:103-107.
• Skolasky, R.L., Phair, J., Detels, R., Riddler, S., Margolick, J., and Jacobson, L.P. (2001). Thrush and fever as markers of immune competence in the era of highly active antiretroviral therapy. AIDS Res. Hum. Retroviruses. 17:1311-1316.
• Detels, R., Tarwater, P., Phair, J.P., Margolick, J., Riddler, S.A., Munoz, A., and the Multicenter AIDS Cohort Study. (2001). Effectiveness of potent antiretroviral therapies on the incidence of opportunistic infections before and after AIDS diagnosis. AIDS 15:347-355.
• Jacobson, L.P., Gore, M.E., Strathdee, S.A., Phair, J.P., Riddler, S., Detels, R., and the Multicenter AIDS Cohort Study. (2001). Therapy naivete in the era of potent antiretroviral therapy. J. Clin. Epidemiol. 54:149-156.
• Cook, R.L., St. George, K., Silvestre, A.J., Riddler, S.A., Lassak, M., and Rinaldo, C.R. Jr. (2002). Prevalence of chlamydia and gonorrhoea among a population of men who have sex with men. Sex. Transm. Infect. 78:190-193.
• Harrold, S.M., Wang, G., McMahon, D.K., Riddler, S.A., Mellors, J.W., Becker, J.T., Caldararo, R., Reinhart, T.A., Achim, C.L., and Wiley, C.A. (2002). Recovery of replication-competent HIV type 1-infected circulating monocytes from individuals receiving antiretroviral therapy. AIDS Res. Hum. Retroviruses. 18:427-434.
• Benson , C.A., Deeks, S.G., Brun, S.C., Gulick, R.M., Eron, J.J., Kessler, H.A., Murphy, R.L., Hicks, C., King, M., Wheeler, D., Feinberg, J., Stryker, R., Sax, P.E., Riddler, S., Thompson, M., Real, K., Hsu, A., Kempf, D., Japour, A.J., and Sun, E. (2002). Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients. J. Infect. Dis. 185:599-607.
• Riddler SA, Havlir D, Squires KE, Kerr B, Lewis RH, Yeh K, Hawe L, Zhong L, Peng Y, Deutsch P, Saah A.  (2002) Co-administration of Indinavir and Nelfinavir in HIV-1 Infected Adults: Safety, Pharmacokinetics and Antiretroviral Activity. Antimicrob Agents and Chemother 46: 3877-3882.
• Lau, B., Gange, S.J., Phair, J.P., Riddler, S.A., Detels, R., and Margolick, J.B. (2003). Rapid declines in total lymphocyte counts and hemoglobin concentration prior to AIDS among HIV-1-infected men. AIDS 17:2035-2044.
• Riddler, S.A., Smit, E., Cole, S.R., Li, R., Chmiel, J.S., Dobs, A., Palella, F., Visscher, B., Evans, R., and Kingsley, L.A. (2003). Impact of HIV infection and HAART on serum lipids in men. JAMA 289:2978-2982.
• Gange, S.J., Lau, B., Phair, J., Riddler, S.A., Detels, R., and Margolick, J.B. (2003). Rapid declines in total lymphocyte count and hemoglobin in HIV infection begin at CD4 lymphocyte counts that justify antiretroviral therapy. AIDS 17:119-121.

• Connolly, N., Manders, E., and Riddler, S.  (2004) Suction-assisted lipectomy for lipodystrophy.  AIDS Res. Hum. Retroviruses.  20:813-915. 

• Kleeberger, C.A., Buechner, J., Palella, F., Detels, R., Riddler, S., Godfrey, R., and Jacobson, L.P. (2004) Changes in adherence to highly active antiretroviral therapy medications in the Multicenter AIDS Cohort Study.
  AIDS 18:683-688.

• Brown, T.T., Cole, S.R., Li, X., Kingsley, L.A., Palella, F.J., Riddler, S.A., Visscher, BR., Margolick, J.B., and Dobs, A.S. (2005) Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study.  Arch. Intern. Med. 165:1179-1184.

• Brown, T.T., Li, X., Cole, S.R., Kingsley, L.A., Palella, F.J., Riddler, S.A., Chmiel, J.S., Visscher, B.R., Margolick, J.B., and Dobs, A.S.  (2005)  Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study.  AIDS 19:1375-1383.

• Lau, B., Gange, S.J., Phair, J.P., Riddler, S.A., Detels, R., and Margolick, J.B. (2005)  Use of total lymphocyte count and hemoglobin concentration for monitoring progression of HIV infection.  J. Acquir. Immune. Defic. Syndr.  39:620-625.

• Seaberg, E.C., Munoz, A., Lu, M., Detels, R., Margolick, J.B., Riddler, S.A., Williams, C.M., Phair, J.P. and the Multicenter AIDS Cohort Study. (2005) Association between highly active antiretroviral therapy and hypertension in a large cohort of men followed from 1984 to 2003.  AIDS 19:953-960.